(3S)-pyrrolidin-3-ol → Nicotinamide

HRID 1887904Notes

Reaction equation

HRID 1887904 reaction equation
Cl[C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8]CC2C(=O)C3C(=CC(Cl)=CC=3)N(C3C=CC=CC=3)C=2)=[O:7])=[CH:4][N:3]=1.O[C@H]1CCNC1>>[C:6]([NH2:8])(=[O:7])[C:5]1[CH:28]=[CH:29][CH:2]=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 2733874(3S)-pyrrolidin-3-olHCID 714870636-chloro-N-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)nicotinamide

Product 1

HCID 936Nicotinamide

Procedure

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-6-(S)-3-hydroxypyrrolidin-1-yl)-nicotinamide was prepared starting from intermediate E and (S)-3-hydroxypyrrolidine. MS calcd. for C26H23ClN4O3 [(M+H)+] 475.2, obsd. 475.0.

Sources & evidence

ORD record
ord-0f2bc9ce9e704933b79719ab1d2d7e6f
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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