4-Methanesulfonylpiperidine hydrochloride → 2-(4-Methanesulfonyl-piperidin-1-yl)-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide

HRID 1887906Notes

Reaction equation

HRID 1887906 reaction equation
Br[C:2]1[S:3][C:4]([C:7]([NH:9][CH2:10][C:11]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][C:16]([Cl:22])=[CH:17][CH:18]=3)[N:13]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:12]=2)=[O:8])=[CH:5][N:6]=1.Cl.[CH3:30][S:31]([CH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)(=[O:33])=[O:32]>>[Cl:22][C:16]1[CH:15]=[C:14]2[C:19]([C:20](=[O:21])[C:11]([CH2:10][NH:9][C:7]([C:4]3[S:3][C:2]([N:37]4[CH2:38][CH2:39][CH:34]([S:31]([CH3:30])(=[O:33])=[O:32])[CH2:35][CH2:36]4)=[N:6][CH:5]=3)=[O:8])=[CH:12][N:13]2[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 230616984-Methanesulfonylpiperidine hydrochlorideHCID 71208954HCID 71208954, compound

Product 1

HCID 712173672-(4-Methanesulfonyl-piperidin-1-yl)-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide

Procedure

2-(4-Methanesulfonyl-piperidin-1-yl)-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate F and 4-methanesulfonyl piperidine hydrochloride. MS calcd. for C26H25ClN4O4S2 [(M+H)+] 557.1, obsd. 557.

Sources & evidence

ORD record
ord-7051ffbd201c4f91be07d4fbb3f04ff6
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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