4-Piperidinemethanol → HCID 71217369, compound

HRID 1887907Notes

Reaction equation

Br[C:2]1[S:3][C:4]([C:7]([NH:9][CH2:10][C:11]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][C:16]([Cl:22])=[CH:17][CH:18]=3)[N:13]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:12]=2)=[O:8])=[CH:5][N:6]=1.[OH:29][CH2:30][CH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[Cl:22][C:16]1[CH:15]=[C:14]2[C:19]([C:20](=[O:21])[C:11]([CH2:10][NH:9][C:7]([C:4]3[S:3][C:2]([N:34]4[CH2:35][CH2:36][CH:31]([CH2:30][OH:29])[CH2:32][CH2:33]4)=[N:6][CH:5]=3)=[O:8])=[CH:12][N:13]2[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 4207714-Piperidinemethanol

HCID 71208954HCID 71208954, compound

Product 1

HCID 71217369HCID 71217369, compound

Procedure

2-(4-Hydroxymethyl-piperidin-1-yl)-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate F and 4-hydroxymethyl piperidine. MS calcd. for C26H25ClN4O3S [(M+H)+] 509.1, obsd. 509.

Sources & evidence

ORD record: ord-ba545ce7fa37454b9a1cbe03140a0c04
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501732B2

Reaction notes

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