Thiomorpholine 1,1-dioxide → HCID 71217372, compound

HRID 1887911Notes

Reaction equation

HRID 1887911 reaction equation
Br[C:2]1[S:3][C:4]([C:7]([NH:9][CH2:10][C:11]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][C:16]([Cl:22])=[CH:17][CH:18]=3)[N:13]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:12]=2)=[O:8])=[CH:5][N:6]=1.[NH:29]1[CH2:34][CH2:33][S:32](=[O:36])(=[O:35])[CH2:31][CH2:30]1>>[Cl:22][C:16]1[CH:15]=[C:14]2[C:19]([C:20](=[O:21])[C:11]([CH2:10][NH:9][C:7]([C:4]3[S:3][C:2]([N:29]4[CH2:34][CH2:33][S:32](=[O:36])(=[O:35])[CH2:31][CH2:30]4)=[N:6][CH:5]=3)=[O:8])=[CH:12][N:13]2[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 6484228Thiomorpholine 1,1-dioxideHCID 71208954HCID 71208954, compound

Product 1

HCID 71217372HCID 71217372, compound

Procedure

2-(1,1-Dioxo-thiomorpholin-4-yl)-thiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate F and thiomorpholine-1,1-dioxide. MS calcd. for C24H21ClN4O4S2 [(M+H)+] 529.1, obsd. 529.

Sources & evidence

ORD record
ord-0b1f42f7f8ae464b8c57af2096ab496d
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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