Triethylamine → HCID 71811133, compound

Participants

Reaction Steps

To a mixture of 3-(aminomethyl)-7-fluoro-1-(2-fluorophenyl)quinolin-4(1H)-one (intermediate H) (470 mg, 1.64 mmol), triethylamine (0.229 mL, 1.64 mmol), and 35 mL of a CH2Cl2-DMF mixture was added 6-chloronicotinoyl chloride (298 mg, 1.64 mmol). The resulting mixture was stirred at room temperature for 1 hr. After this time, the reaction was complete, giving 6-chloro-N-[7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-yl-methyl]-nicotinamide (500 mg, 72%). MS calcd. for C22H14ClF2N3O2 [(M+H)+] 426.1, obsd. 426.1.

Provenance & Evidence