Thiomorpholine 1,1-dioxide → HCID 71208231, compound

HRID 1887919Notes

Reaction equation

HRID 1887919 reaction equation
Cl[C:2]1[CH:30]=[CH:29][C:5]([C:6]([NH:8][CH2:9][C:10]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][C:15]([F:21])=[CH:16][CH:17]=3)[N:12]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[F:28])[CH:11]=2)=[O:7])=[CH:4][N:3]=1.[NH:31]1[CH2:36][CH2:35][S:34](=[O:38])(=[O:37])[CH2:33][CH2:32]1>>[O:37]=[S:34]1(=[O:38])[CH2:35][CH2:36][N:31]([C:2]2[CH:30]=[CH:29][C:5]([C:6]([NH:8][CH2:9][C:10]3[C:19](=[O:20])[C:18]4[C:13](=[CH:14][C:15]([F:21])=[CH:16][CH:17]=4)[N:12]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[F:28])[CH:11]=3)=[O:7])=[CH:4][N:3]=2)[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 6484228Thiomorpholine 1,1-dioxideHCID 71811133HCID 71811133, compound

Product 1

HCID 71208231HCID 71208231, compound

Procedure

6-(1,1-Dioxo-1-thiomorpholin-4-yl)-N-[7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-ylmethyl]-nicotinamide was prepared starting from 6-chloro-N-[7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-yl-methyl]-nicotinamide (example I-105) and thiomorpholine-1,1-dioxide. MS calcd. for C26H22F2N4O4S [(M+H)+] 525.1, obsd. 525.2.

Sources & evidence

ORD record
ord-1486f228d55f4d80beae9e4106bf6c98
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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