1,3-Benzothiazole-5-carboxylic acid → 3-{[(Benzothiazole-5-carbonyl)-amino]-methyl}-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

HRID 1887922Notes

Reaction equation

HRID 1887922 reaction equation
Cl.[CH3:2][O:3][C:4]([C:6]1[N:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:8]2[C:13]([C:14](=[O:18])[C:15]=1[CH2:16][NH2:17])=[CH:12][CH:11]=[C:10]([Cl:19])[CH:9]=2)=[O:5].[S:26]1[C:30]2[CH:31]=[CH:32][C:33]([C:35](O)=[O:36])=[CH:34][C:29]=2[N:28]=[CH:27]1>>[CH3:2][O:3][C:4]([C:6]1[N:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:8]2[C:13]([C:14](=[O:18])[C:15]=1[CH2:16][NH:17][C:35]([C:33]1[CH:32]=[CH:31][C:30]3[S:26][CH:27]=[N:28][C:29]=3[CH:34]=1)=[O:36])=[CH:12][CH:11]=[C:10]([Cl:19])[CH:9]=2)=[O:5]

Participants

3

Reactant 2

HCID 27354601,3-Benzothiazole-5-carboxylic acidHCID 712085323-Aminomethyl-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester hydrochloride

Product 1

HCID 712085013-{[(Benzothiazole-5-carbonyl)-amino]-methyl}-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester

Procedure

3-{[(Benzothiazole-5-carbonyl)-amino]-methyl}-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester was prepared starting from intermediate I and benzothiazole-5-carboxylic acid. MS calcd. for C26H19ClN3O4S [(M+H)+] 504.1, obsd. 503.9.

Sources & evidence

ORD record
ord-f3ae58f716e94f559cd4b393481c7fa3
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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