1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid → HCID 71208728, compound

HRID 1887923Notes

Reaction equation

HRID 1887923 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:31])[C:7]([CH2:18][NH:19][C:20]([C:22]3[CH:23]=[C:24]4NC=NC4=N[CH:27]=3)=[O:21])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.[C:32]([O:36][C:37]([N:39]1[CH2:44]CC(C(O)=O)CC1)=[O:38])([CH3:35])([CH3:34])[CH3:33]>>[CH3:32][O:36][C:37]([C:8]1[N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]2[C:5]([C:6](=[O:31])[C:7]=1[CH2:18][NH:19][C:20]([CH:22]1[CH2:23][CH2:24][N:39]([C:37]([O:36][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:38])[CH2:44][CH2:27]1)=[O:21])=[CH:4][CH:3]=[C:2]([Cl:1])[CH:11]=2)=[O:38]

Participants

3

Reactant 2

HCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 71229291HCID 71229291, compound

Product 1

HCID 71208728HCID 71208728, compound

Procedure

3-{[(1-tert-butoxycarbonyl-piperidine-4-carbonyl)-amino]-methyl}-7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester was prepared starting from intermediate 1 and 1-tert-butoxycarbonyl-piperidine-4-carboxylic acid. MS calcd. for C29H33ClN3O6 [(M+H)+] 554.2, obsd. 554.1.

Sources & evidence

ORD record
ord-8a373e64560747759d7ad48dc657eef2
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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