4-(1H-Pyrazol-5-yl)benzoic acid → HCID 71208396, compound

Participants

Reaction Steps

4-oxo-1-phenyl-3-{[4-(2H-pyrazol-3-yl)-benzoylamino]-methyl}-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester was prepared starting from intermediate J and 4-(2H-pyrazol-3-yl)-benzoic acid. 1H NMR (300 MHz, DMSO-d6) δ ppm 12.99 (br. s., 1H) 8.90 (d, J=7.85 Hz, 1H) 8.52 (br. s., 1H) 7.97 (d, J=8.15 Hz, 1H) 7.77-7.90 (m, 5H) 7.51-7.60 (m, 3H) 7.43 (dd, J=6.79, 2.87 Hz, 2H) 6.79 (s, 1H) 4.46 (d, J=4.53 Hz, 2 H) 3.38 (s, 3H) LCMS calcd. for C28H20F3N5O4 [(M+H)+] 547.1, obsd. 548.1.

Provenance & Evidence