HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-indole-6-carboxylic acid → HCID 71208741, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-indole-6-carboxylic acid | HCID 595230 | — |
| Reactant | 3-Aminomethyl-4-oxo-1-phenyl-7-trifluoromethyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester hydrochloride | HCID 71208427 | — |
| Product | HCID 71208741 | HCID 71208741 | — |
Reaction Steps
3-{[(1H-Indole-6-carbonyl)-amino]-methyl}-4-oxo-1-phenyl-7-trifluoromethyl-1,4-di-hydro-[1,8]naphthyridine-2-carboxylic acid methyl ester was prepared starting from intermediate J and 1H-indole-6-carboxylic acid. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.35 (br. s., 1H) 8.90 (d, J=8.15 Hz, 1H) 8.36 (br. s., 1H) 7.96 (d, J=8.15 Hz, 1H) 7.89 (s, 1H) 7.37-7.59 (m, 8 H) 6.46 (br. s., 1H) 4.47 (d, J=4.83 Hz, 2H) 3.37 (s, 3H) MS calcd. for C27H19F3N4O4 [(M+H)+] 521.1 obsd. 521.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501732B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-24275aff55774b269285e4185771ea62 |
| Source note | uspto-grants-2013_08 |