3,4-Difluorobenzoyl chloride → HCID 71208770, compound

HRID 1887938Notes

Reaction equation

HRID 1887938 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[CH:9][CH:10]=2)[N:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:4]=1[C:22]([O:24][CH3:25])=[O:23].[F:26][C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][C:35]=1[F:36])[C:30](Cl)=[O:31]>>[CH3:25][O:24][C:22]([C:4]1[N:5]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:30](=[O:31])[C:29]1[CH:33]=[CH:34][C:35]([F:36])=[C:27]([F:26])[CH:28]=1)=[CH:10][CH:9]=[C:8]([O:14][CH3:15])[CH:7]=2)=[O:23]

Participants

3

Reactant 2

HCID 27245193,4-Difluorobenzoyl chlorideHCID 71208438HCID 71208438, compound

Product 1

HCID 71208770HCID 71208770, compound

Procedure

7-Methoxy-3-[(3,4-difluoro-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quino-line-2-carboxylic acid methyl ester was prepared starting from intermediate K and 3,4-difluorobenzoyl chloride. MS calcd. for C26H20F2N2O5 [(M+H)+] 479.1, obsd. 479.1.

Sources & evidence

ORD record
ord-954ddaf7b24644aa997a191421cfc78d
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

Loading…