Nicotinoyl chloride → HCID 71208704, compound

HRID 1887941Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[CH:9][CH:10]=2)[N:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:4]=1[C:22]([O:24][CH3:25])=[O:23].[N:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32](Cl)=[O:33])[CH:27]=1>>[CH3:25][O:24][C:22]([C:4]1[N:5]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:32]([C:28]1[CH:27]=[N:26][CH:31]=[CH:30][CH:29]=1)=[O:33])=[CH:10][CH:9]=[C:8]([O:14][CH3:15])[CH:7]=2)=[O:23]

Participants

Reactant 2

HCID 82604Nicotinoyl chloride

HCID 71208438HCID 71208438, compound

Product 1

HCID 71208704HCID 71208704, compound

Procedure

7-Methoxy-4-oxo-1-phenyl-3-{[(pyridine-3-carbonyl)-amino]-methyl}-1,4-dihydroquin-oline-2-carboxylic acid methyl ester was prepared starting from intermediate K and pyridine-3-carbonyl chloride. MS calcd. for C25H21N3O5 [(M+H)+] 444.2, obsd. 444.0.

Sources & evidence

ORD record: ord-553b2f9256014df8b72552a39f045e89
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501732B2

Reaction notes

Loading…