4-Fluorobenzoyl chloride → HCID 71208938, compound

HRID 1887942Notes

Reaction equation

HRID 1887942 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[CH:9][CH:10]=2)[N:5]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:4]=1[C:22]([O:24][CH3:25])=[O:23].[F:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1>>[CH3:25][O:24][C:22]([C:4]1[N:5]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:31](=[O:32])[C:30]1[CH:34]=[CH:35][C:27]([F:26])=[CH:28][CH:29]=1)=[CH:10][CH:9]=[C:8]([O:14][CH3:15])[CH:7]=2)=[O:23]

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 71208438HCID 71208438, compound

Product 1

HCID 71208938HCID 71208938, compound

Procedure

3-[(4-Fluoro-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester was prepared starting from intermediate K and 4-fluorobenzoyl chloride. MS calcd. for C26H21FN2O5 [(M+H)+] 461.1, obsd. 460.9.

Sources & evidence

ORD record
ord-f32ed88289d1415a8e6a20b9a3d96d1c
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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