4-Chlorobenzoyl chloride → HCID 71208588, compound

HRID 1887943Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[N:6]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:7]2[C:12]([C:13](=[O:28])[C:14]=1[CH2:15][NH:16][C:17](=[O:27])[C:18]1[CH:23]=[CH:22][C:21](N(C)C)=[CH:20][CH:19]=1)=[CH:11][CH:10]=[C:9]([O:29][CH3:30])[CH:8]=2)=[O:4].NCC1C(=O)C2C(=CC(OC)=CC=2)N(C2C=CC=CC=2)C=1C(OC)=O.[Cl:62]C1C=CC(C(Cl)=O)=CC=1>>[CH3:1][O:2][C:3]([C:5]1[N:6]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:7]2[C:12]([C:13](=[O:28])[C:14]=1[CH2:15][NH:16][C:17](=[O:27])[C:18]1[CH:23]=[CH:22][C:21]([Cl:62])=[CH:20][CH:19]=1)=[CH:11][CH:10]=[C:9]([O:29][CH3:30])[CH:8]=2)=[O:4]

Participants

Reactant 3

HCID 85014-Chlorobenzoyl chloride

HCID 71208438HCID 71208438, compound

HCID 71209044HCID 71209044, compound

Product 1

HCID 71208588HCID 71208588, compound

Procedure

3-[(4-Dimethylamino-benzoylamino)-methyl]-7-methoxy-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid methyl ester as prepared starting from intermediate K and 4-chloro-benzoyl chloride. MS calcd. for C26H21ClN2O5 [(M+H)+] 477.1, obsd. 477.1.

Sources & evidence

ORD record: ord-42c04ea027024e67ba3938109d55f02a
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501732B2

Reaction notes

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