7-Fluoroquinazolin-4-amine → HCID 71208519, compound

HRID 1887945Notes

Reaction equation

HRID 1887945 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:32])[C:7]([CH2:18][NH:19][C:20](=O)OC3C=CC([N+]([O-])=O)=CC=3)=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.[F:33][C:34]1[CH:43]=[C:42]2[C:37](C(N)=[N:39][CH:40]=[N:41]2)=[CH:36][CH:35]=1>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:32])[C:7]([CH2:18][NH:19][C:20]3[C:37]4[C:42](=[CH:43][C:34]([F:33])=[CH:35][CH:36]=4)[N:41]=[CH:40][N:39]=3)=[CH:8][N:9]2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 468357077-Fluoroquinazolin-4-amineHCID 866757694-Nitrophenyl (7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methylcarbamate

Product 1

HCID 71208519HCID 71208519, compound

Procedure

7-Chloro-3-[(7-fluoro-quinazolin-4-ylamino)-methyl]-1-phenyl-1H-quinolin-4-one was prepared according to the procedure described above for example 12-1, starting with intermediate M and 7-fluoro-quinazolin-4-amine. MS calcd. for C24H16ClFN4O [(M+H)+] 430.9, obsd. 431.3

Sources & evidence

ORD record
ord-acb67d4088154bde91a22055cd0d83c8
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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