4-Nitrophenyl (7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methylcarbamate → HCID 71208468, compound

HRID 1887953Notes

Reaction equation

HRID 1887953 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:32])[C:7]([CH2:18][NH:19][C:20](=[O:31])OC3C=CC([N+]([O-])=O)=CC=3)=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.[C:33]([O:37][C:38](=[O:47])[NH:39][C@H:40]1[CH2:45][CH2:44][C@H:43]([NH2:46])[CH2:42][CH2:41]1)([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38](=[O:47])[NH:39][CH:40]1[CH2:41][CH2:42][CH:43]([NH:46][C:20]([NH:19][CH2:18][C:7]2[C:6](=[O:32])[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:8]=2)=[O:31])[CH2:44][CH2:45]1)([CH3:36])([CH3:34])[CH3:35]

Participants

3

Reactant 2

HCID 866757694-Nitrophenyl (7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methylcarbamateHCID 178419079HCID 178419079, compound

Product 1

HCID 71208468HCID 71208468, compound

Procedure

{4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-cyclohexyl}-carbamic acid tert-butyl ester was prepared was prepared starting from intermediate M and trans-(4-amino-cyclohexyl)-carbamic acid tert-butyl ester. MS calcd. for C28H34ClN4O4 [(M+H)+] 525.2, obsd. 525.1.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-c75777d26475429ca9962de06eaf5a83
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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