4-Nitrophenyl (7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methylcarbamate → 4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-cyclohexane-carboxylic acid methyl ester

HRID 1887960Notes

Reaction equation

HRID 1887960 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:32])[C:7]([CH2:18][NH:19][C:20](=O)[O:21]C3C=CC([N+]([O-])=O)=CC=3)=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.[CH3:33][O:34][C:35]([C@H:37]1[CH2:42][CH2:41][C@H:40]([NH2:43])[CH2:39][CH2:38]1)=[O:36]>>[CH3:33][O:34][C:35]([CH:37]1[CH2:42][CH2:41][CH:40]([NH:43][C:20]([NH:19][CH2:18][C:7]2[C:6](=[O:32])[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=2)=[O:21])[CH2:39][CH2:38]1)=[O:36]

Participants

3

Reactant 2

HCID 866757694-Nitrophenyl (7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methylcarbamateHCID 178501207HCID 178501207, compound

Product 1

HCID 712087364-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-cyclohexane-carboxylic acid methyl ester

Procedure

4-[3-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-ureido]-cyclohexane-carboxylic acid methyl ester was prepared starting from intermediate M and trans-4-amino-cyclohexane carboxylic acid methyl ester. MS calcd. for C25H27ClN3O4 [(M+H)+] 468.2, obsd. 468.1.

Sources & evidence

ORD record
ord-cd7becd7ead34d23b5236b6f05d7069a
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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