Diisopropylethylamine → HCID 71208146, compound

Participants

Reaction Conditions

Reaction Steps

In a 20 mL round-bottomed flask, 4-nitrophenyl 4-(3-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)ureido)piperidine-1-carboxylate (0.100 g, 0.174 mmol), N,N-diisopropylethylamine (112 mg, 152 μL, 0.868 mmol) and 4-(methylsulfonyl)-piperidine (28.3 mg, 0.174 mmol) were combined with DMF (5 mL). The reaction mixture was stirred at 100° C. over the weekend. The reaction mixture was concentrated. The crude product was purified by preparative reverse-phase HPLC, giving the product 1-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3-[1-(4-methanesulfonyl-piperidine-1-carbonyl)-piperidin-4-yl]-urea. MS calcd. for C29H35ClN5O5S [(M+H)+] 600.2, obsd. 600.0.

Provenance & Evidence