4-(Dimethylamino)phenyl isocyanate → HCID 71208233, compound

HRID 1887972Notes

Reaction equation

HRID 1887972 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[CH3:21][N:22]([CH3:32])[C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:30]([NH:29][C:26]3[CH:27]=[CH:28][C:23]([N:22]([CH3:32])[CH3:21])=[CH:24][CH:25]=3)=[O:31])=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 27333724-(Dimethylamino)phenyl isocyanateHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208233HCID 71208233, compound

Procedure

1-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3-(4-dimethylamino-phenyl)-urea was prepared starting from intermediate D and 4-(dimethylamino)-phenylisocyanate. MS calcd. for C25H24ClN4O2 [(M+H)+] 447.2, obsd. 447.2.

Sources & evidence

ORD record
ord-0e50ae17f429442a8ed0866a4ac57011
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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