1-Chloro-2-fluoro-4-isocyanato-benzene → HCID 71208573, compound

HRID 1887974Notes

Reaction equation

HRID 1887974 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][C:23]=1[F:31]>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:1][CH2:2][C:3]2[C:12](=[O:13])[C:11]3[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=3)[N:5]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:4]=2)=[O:30])=[CH:24][C:23]=1[F:31]

Participants

3

Reactant 2

HCID 130033651-Chloro-2-fluoro-4-isocyanato-benzeneHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208573HCID 71208573, compound

Procedure

1-(4-Chloro-3-fluoro-phenyl)-3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-yl-methyl)-urea was prepared starting from intermediate D and 4-chloro-3-fluoro-phenylisocyanate. MS calcd. for C23H17Cl2FN3O2 [(M+H)+] 456.1, obsd. 455.9.

Sources & evidence

ORD record
ord-7f32da1b8db6452f881acf360d9d2c45
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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