p-(Trifluoromethoxy)phenyl isocyanate → HCID 71208229, compound

HRID 1887975Notes

Reaction equation

HRID 1887975 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[F:21][C:22]([F:34])([F:33])[O:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1>>[F:21][C:22]([F:33])([F:34])[O:23][C:24]1[CH:25]=[CH:26][C:27]([NH:30][C:31]([NH:1][CH2:2][C:3]2[C:12](=[O:13])[C:11]3[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=3)[N:5]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:4]=2)=[O:32])=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 92298p-(Trifluoromethoxy)phenyl isocyanateHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208229HCID 71208229, compound

Procedure

1-(4-trifluoromethoxy-phenyl)-3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-yl-methyl)-urea was prepared starting from intermediate D and 4-trifluoromethoxy-phenylisocyanate. MS calcd. for C24H8ClF3N3O3 [(M+H)+] 488.1, obsd. 488.0.

Sources & evidence

ORD record
ord-8e7ebc76b243416faaee02f6609aa757
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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