Hydrochloric Acid → HCID 67304670, compound

Participants

Reaction Steps

To a solution of tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}-1-methylethyl)carbamate (27 mg) in dichloromethane (1 mL) was added a solution of hydrogen chloride in ethyl acetate (80 ul). The reaction was allowed to stir at room temperature for 1 h. Upon completion of the reaction, diisopropylether was added to the suspension and the solid was filtered to give the product (19 mg, 71%). 400 M Hz 1H-NMR (DMSO-d6) δ: 8.90-8.70 (m, 3H), 8.37 (d, J=8.3 Hz, 2H), 8.15 (dd, J=6.0 Hz and 1.8 Hz, 1H), 8.08-8.03 (m, 3H), 7.86 (dd, J=7.3 Hz and 1.4 Hz, 1H), 7.79 (d, J=8.7 Hz, 2H), 7.67 (d, J=8.7 Hz, 2H), 7.52-7.47 (m, 2H), 7.46-7.41 (m, 1H), 6.89 (dd, J=7.3 Hz and 6.4 Hz, 1H), 1.70 (s, 6H); LCMS: 421 [M+H].

Provenance & Evidence