HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → Donepezil methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Donepezil methanesulfonate | HCID 131730793 | — |
Reaction Steps
Methanesulfonic acid (0.65 ml, dissolved in 35 ml of 2-propanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 182.2° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-ad20accefd364bd9ba3c6b8e3865eedd |
| Source note | uspto-grants-2013_08 |