Donepezil → Donepezil methanesulfonate

Participants

Reaction Steps

Methanesulfonic acid (1.3 ml, dissolved in 11 ml of absolute ethanol and 50 ml of dipropyl ether) is slowly added to a solution of Donepezil (3.79 g) in absolute ethanol (38 ml) with stirring at room temperature. The mixed solution is stirred at room temperature and the solid precipitated is filtered and dried 55° C. under vacuum to give the title compound. Melting point: 177.4° C.

Provenance & Evidence