HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → HCID 86648412, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86648412 | HCID 86648412 | — |
Reaction Steps
Para-toluenesulfonic acid (1.902 g, dissolved in 35 ml of acetone) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (70 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 170.8° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-3b1ca8e4a8a543fa92c67a9d04a70816 |
| Source note | uspto-grants-2013_08 |