2,3-Dihydroxybutanedioic Acid → HCID 86648414, compound

HRID 1888033Notes

Reaction equation

HRID 1888033 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[C:29]([OH:38])(=[O:37])[CH:30]([CH:32]([C:34]([OH:36])=[O:35])[OH:33])[OH:31]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[C:34]([CH:32]([CH:30]([C:29]([O-:38])=[O:37])[OH:31])[OH:33])([O-:36])=[O:35]

Participants

4

Reactant 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 3152Donepezil

Product 1

HCID 86648414HCID 86648414, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Donepezil (3.79 g, dissolved in 70 ml of ethyl acetate) is slowly added to a solution of tartaric acid (0.75 g) in absolute ethanol (35 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 168.0° C.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

Sources & evidence

ORD record
ord-c3776412830c41949ed0ef9ba7ae6acc
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

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