Phosphoric Acid → HCID 11677224, compound

HRID 1888045Notes

Reaction equation

HRID 1888045 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[P:29](=[O:33])([OH:32])([OH:31])[OH:30]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[P:29]([O-:33])([O-:32])([O-:31])=[O:30]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 3152Donepezil

Product 1

HCID 11677224HCID 11677224, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Donepezil (3.79 g, dissolved in 70 ml of ethyl acetate) is slowly added to a solution of phosphoric acid (0.29 ml) in acetone (35 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound.

Workup

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

Sources & evidence

ORD record
ord-b86c32b56e1e4e72a277cb6d29e4174c
Source dataset
uspto-grants-2013_08
Patent number
US08501779B2

Reaction notes

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