HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → HCID 24801487, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 24801487 | HCID 24801487 | — |
Reaction Steps
Donepezil (3.79 g, dissolved in 70 ml of ethyl acetate) is slowly added to a solution of fumaric acid (0.58 g) in 2-propanol (35 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 173.1° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-f04db331eab44d1db49dc6ef1cd5a128 |
| Source note | uspto-grants-2013_08 |