反应详情

Donepezil (3.79 g, dissolved in 70 ml of ethyl acetate) is slowly added to a solution of maleic acid (0.58 g) in absolute ethanol (35 ml) with stirring at room temperature. The mixture is stirred for 3 hours at room temperature and concentrated at vacuum to give the title compound.

1. stirringThe mixture is stirred for 3 hours at room temperature
2. concentrationconcentrated at vacuum