Donepezil → Donepezil Maleate

Participants

Reaction Steps

Maleic acid (1.161 g, dissolved in 10 ml of absolute ethanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature followed by adding 10 ml of dipropyl ether. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 132.2° C.

Provenance & Evidence