HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → Donepezil Maleate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Donepezil Maleate | HCID 24801486 | — |
Reaction Steps
Donepezil (3.79 g, dissolved in 20 ml of ethyl acetate) is slowly added to a solution of maleic acid (0.58 g) in 2-propanol (5 ml) with stirring at room temperature. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 129.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501779B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-d4d2faf191444ca49fb751c397ddee19 |
| Source note | uspto-grants-2013_08 |