Sodium Iodide → N-benzyl-4-(p-chlorobenzoylmethyl)-4-piperidinol hydrobromide

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Reaction Steps

Anhydrous cerium chloride (0.99 g, 4.0 mmol) and sodium iodide (1.8 g, 12.0 mmol) are added to 10 ml of anhydrous tetrahydrofuran as a solvent to form a suspension. Dissolving 0.98 g (4.0 mmol) of 2-bromo-1-(4-chlorophenyl)ethanone and 0.76 g (4.0 mmol) of N-benzyl-4-piperidone in 10 ml of anhydrous tetrahydrofuran, and the solution is added dropwise to the above suspension and reacting at room temperature for 2 hours. Operating according to the post-treatment procedure in General Method three, and a salt is formed by acidifying with hydrobromic acid/ethanol solution, which is recrystallized in ethanol to obtain 0.65 g of a white crystal, with yield of 36.7%.

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