Thionyl Chloride → HCID 67119973, compound

Participants

Reaction Steps

N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-benzoylmethyl-4-piperidinol (III-13) is firstly prepared according to the method of synthesis and post-treatment in Example 13. 1.41 g (4.0 mmol) of N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-benzoylmethyl-4-piperidinol is dissolved into 20 ml of anhydrous dichloromethane and cooled in an ice-water bath with temperature controlled at below 0° C. The reaction solution is added dropwise a dichloromethane solution (8 mol, 25 ml) of SOCl2. After completion of addition, the temperature is raised to room temperature slowly and reacting for 1 hour. Then operating according to the post-treatment method in General Method seven obtains 0.65 g of a white crystal, with yield of 38.1%.

Provenance & Evidence