1,4-Dioxane → HCID 68478946, compound

Participants

Reaction Steps

A solution of (3S,4S)-tert-butyl 4-(4-chlorophenyl)-3,4-dihydroxy-3-methylpiperidine-1-carboxylate (388 mg, 1.135 mmol) in 4 M HCl in dioxane (10 mL, 40.0 mmol) was stirred at room temperature for 2 hours. The mixture was concentrated in-vacuo, then concentrated 3× from methylene chloride to remove residual HCl and dioxane, to yield the title compound. MS (ESI+)=242.2 (M+H)+, 224.2 (M+H−H2O)+.

Provenance & Evidence