Ammonia → Flunixin

HRID 1888131노트

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HRID 1888131 반응식
[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CS(C1C=CC([C@@H](O)[C@H](NC(C(Cl)Cl)=O)CF)=CC=1)(=O)=O.N>O>[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:20])([F:19])[F:21]

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 56843417Resflor

생성물 1

HCID 38081Flunixin수율 100%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

About 300 g of Resflor® is added over about 1 hour to a stirring solution of about 24 mL of concentrated ammonia in about 3 L of water heated to about 50° C. Additional concentrated ammonia can be added to ensure that the pH is about 9. The mixture is stirred and cooled to room temperature. The resulting precipated Florfenicol is removed by filtration. The filtrate is acidifed to about pH 4.5 with 10% H2SO4 then stirred for about another 1 hour. The resulting precipitated Flunixin is collected by filtration then dried to a moisture content of less than about 1% to yield about 4 g of crude Flunixin (100%).

후처리

  1. temperaturecooled to room temperature
  2. customThe resulting precipated Florfenicol is removed by filtration
  3. stirringthen stirred for about another 1 hour
  4. customThe resulting precipitated Flunixin
  5. filtrationis collected by filtration
  6. customthen dried to a moisture content of less than about 1%

출처 및 근거

ORD 기록
ord-aa034fbb34ea4023ae02c6dcb9a4a230
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501788B2

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