Potassium Carbonate → HCID 28819282, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 80 mg (0.70 mmol) of L-Proline in 3 mL of anhydrous N,N-dimethylformamide at ambient temperature was added 0.062 ml (0.70 mmol) of 2-bromothiazole, 288 mg (2.09 mmol) of potassium carbonate, and 13 mg (0.068 mmol) of copper(I)iodide. The reaction mixture was heated to 100° C. overnight then filtered through a plug of Celite®. The crude residue was purified by reverse-phase HPLC (TMC Pro-Pac C18; 0-60% 0.1% trifluoroacetic acid in acetonitrile/0.1% trifluoroacetic acid in water gradient). The pure fractions were lyophilized overnight to give the title compound as a light brown solid. (0.065 g, 50%). LC-MS: m/z (ES) 199.2 (MH)+.

Provenance & Evidence