反应详情

温度

100 °C

To a solution of 1.87 g (22.3 mmol) of methyl prop-2-ynoate in 40 mL of toluene was added 1.9 g (11 mmol) of tert-butyl 2-azidopropanate. The reaction mixture was heated at 100° C. for 3 h then cooled to ambient temperature. All volatiles were removed under reduced pressure and the crude residue purified by column chromatography on silica gel eluting with a 5 to 25% acetone in hexanes gradient to afford the title compounds.

1. temperaturethen cooled to ambient temperature
2. customAll volatiles were removed under reduced pressure
3. customthe crude residue purified by column chromatography on silica gel eluting with a 5 to 25% acetone in hexanes gradient