Piperidine → HCID 58125131, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3.15 g (4.65 mmol) of tert-butyl(2S,5R)-2-{4-[((2S)-2-{[(9H-fluoren-9-yloxy)carbonyl]amino}propanoyl)amino]benzyl}-5-[(R)-hydroxy(pyridin-3-ylmethyl]pyrrolidine-1-carboxylate from step A in 3 mL of anhydrous THF was added 0.396 g (4.65 mmol) of piperidine. The resulting mixture was heated to 35° C. under an atmosphere of nitrogen for 2 h then all volatiles were removed in vacuo to afford the crude title compound which was used without further purification. LC-MS: m/z (ES) 455 (MH)+.

Provenance & Evidence