反应详情

To 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (0.30 g, 0.74 mmols) in 2-methyl-2-propanol (30 mL) was added KOH (0.45 g, 7.4 mmol). The reaction mixture was heated at reflux overnight. After cooling, the solvent was evaporated and the residue was redissovled in ethyl acetate (150 mL) and filtered through a pad of silica gel to give the title compound (300 mg) as a yellow solid (99%).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux overnight
3. temperatureAfter cooling
4. customthe solvent was evaporated
5. filtrationfiltered through a pad of silica gel