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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1888233Generated: November 1, 2026

Benzenesulfonyl chloride → HCID 178513522, compound

https://huagongshe.com/reaction/1888233

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenesulfonyl chlorideHCID 7369—
ReactantTriethylamineHCID 8471—
Reactant5-phenyl-3-(4-piperidinyl)-1H-indazole-7-carboxamide hydrochlorideHCID 178479539—
Catalyst4-(Dimethylamino)pyridineHCID 14284—
SolventDimethylformamideHCID 6228—
ProductHCID 178513522HCID 1785135228.9%

Reaction Steps

This compound was prepared in a fashion analogous to the procedure described in Example 3. Thus, 5-phenyl-3-(4-piperidinyl)-1H-indazole-7-carboxamide hydrochloride (0.057 g, 0.17 mmol) was reacted with phenylsulfonyl chloride (0.022 mL, 0.17 mmol) in the presence of triethylamine (0.1 mL, 0.71 mmol) and DMAP (0.0021 g, 0.017 mmol) in DMF (3 mL) to give 0.007 g of pale yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08501780B2
Source datasetuspto-grants-2013_08
ORD IDord-5901fa48cc914f858a246de6aa3801d4
Source noteuspto-grants-2013_08