HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzenesulfonyl chloride → HCID 178510108, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzenesulfonyl chloride | HCID 39497 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-phenyl-3-(4-piperidinyl)-1H-indazole-7-carboxamide hydrochloride | HCID 178479539 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | HCID 178510108 | HCID 178510108 | 41.2% |
Reaction Steps
Following the general procedure of Example 11, 5-phenyl-3-(4-piperidinyl)-1H-indazole-7-carboxamide hydrochloride (Example 2) (50 mg, 0.14 mmol), diisopropylethylamine (100 uL, 0.56 mmol), DMAP (25 mg, 0.014 mmol) and 4-cyanobenzenesulfonyl chloride (34 mg, 0.168 mmol) were reacted to give the title compound (28 mg, 41%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501780B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-bfed58117c3b4f698d65a4e047f5c118 |
| Source note | uspto-grants-2013_08 |