HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 178513541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(3-fluorophenyl)-1H-indazole-7-carboxamide | HCID 178513540 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178513541 | HCID 178513541 | 21% |
Reaction Steps
The title compound was prepared according to the general procedure of Example 38b. Thus, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(3-fluorophenyl)-1H-indazole-7-carboxamide (Example 38a) (0.222 mmol) in DMF (4 mL) was reacted with K2CO3 (61 mg, 0.444 mmol) and pyrrolidine (92 uL, 1.11 mmol) to afford the title compound (23.5 mg, 21% for 2 steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501780B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-240916d826c9446d8db7a3eca0b8aa2b |
| Source note | uspto-grants-2013_08 |