HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 178513544, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(3-fluorophenyl)-1H-indazole-7-carboxamide | HCID 178513540 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178513544 | HCID 178513544 | 32.1% |
Reaction Steps
The title compound was prepared according to the general procedure of Example 38b. Thus, 3-{1-[(3-Chloropropyl)sulfonyl]-4-piperidinyl}-5-(3-fluorophenyl)-1H-indazole-7-carboxamide (Example 38a) (0.222 mmol) in DMF (4 mL) was reacted with K2CO3 (61 mg, 0.444 mmol) and morpholine (97 uL, 1.11 mmol) to afford the title compound (37.73 mg, 32% for 2 steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501780B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-5288b6ebae9f467d89c747c2547d68d7 |
| Source note | uspto-grants-2013_08 |