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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1888273Generated: November 2, 2026

Dimethylamine → HCID 178483614, compound

https://huagongshe.com/reaction/1888273

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamineHCID 674—
ReactantSodium IodideHCID 5238—
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 178513558HCID 178513558—
SolventDimethylformamideHCID 6228—
ProductHCID 178483614HCID 17848361438.5%

Reaction Steps

The title compound was prepared according to the general procedure of Example 38b. Thus, 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-(2-thienyl)-1H-indazole-7-carboxamide (Example 46a) (0.076 mmol) in DMF (4 mL) was reacted with K2CO3 (22 mg, 0.16 mmol), sodium iodide (2 mg) and dimethyl amine (0.2 mL, 0.4 mmol) to afford the title compound (13.9 mg, 38%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08501780B2
Source datasetuspto-grants-2013_08
ORD IDord-54ccce187fd3435c85e090d8bfbd83c8
Source noteuspto-grants-2013_08