Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Methylsulfonylaminophenylboronic acid | HCID 2773535 | — |
| Reactant | HCID 178451813 | HCID 178451813 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 178451816 | HCID 178451816 | — |
Reaction Steps
A mixture of 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-bromo-1H-indazol-3-yl]-1-piperidinecarboxylate (Intermediate 5) (30 mg, 0.07 mmols), {3-[(methylsulfonyl)amino]phenyl}boronic acid (46 mg, 0.21 mmols), cesium carbonate (150 mg), and Pd(PPh3)4 (10 mg) in dioxane/water (3/1, 4 mL) was heated at 160° C. for 2700 secs. (microwave irradiation). The resulting mixture was concentrated, redissolved in methylene chloride and filtered. The filtrate was concentrated and used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08501780B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-0e9100d36a1e4f78b556c2a0b7d3d2d2 |
|---|
| Source note | uspto-grants-2013_08 |
|---|
