AcOH THF water → HCID 11268538, compound

Participants

Reaction Conditions

Reaction Steps

To the compound 23 (171 mg) was added acetic acid/tetrahydrofuran/water (65:10:35) (4.00 mL) and the solution was stirred at 50° C. for 50 minutes. The reaction solution was diluted with ethyl acetate, washed with water and brine, dried over anhydrous magnesium sulfate and concentrated. The obtained residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1), to give the title compound (119 mg) having the following physical data.

Provenance & Evidence