Sodium Bicarbonate → HCID 68768429, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound 41 (10.1 g) in dimethoxyethane (79 mL) was slowly added dropwise potassium hexamethyldisilazide (0.5M in toluene, 47.5 mL) at −78° C. and the solution was stirred at −78° C. for 54 minutes. To the reaction solution was slowly added dropwise a solution of the compound 42 (9.84 g) in dimethoxyethane (79 mL) and the solution was stirred at −78° C. for 25 minutes. The solution temperature was risen to 0° C. and the solution was stirred for 50 minutes. To the reaction solution was added an aqueous saturated sodium bicarbonate solution and the solution was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium bicarbonate solution and brine, and dried over anhydrous magnesium sulfate. The reaction solution was filtrated through Celite (Brand name) and concentrated. The obtained residue was purified by Yamazen Parallel Prep (Brand name; column: 3 L, inject column: 2 L, n-hexane:ethyl acetate=84:16) to give the title compound (6.62 g) having the following physical data.

Provenance & Evidence