Sodium Bicarbonate → HCID 66857634, compound

Participants

Reaction Steps

To a solution of the compound 43 (6.53 g) in ethyl acetate (114 mL) was slowly added dropwise 4N hydrogen chloride/ethyl acetate solution (14 mL) at 0° C. and the solution was stirred for 10 minutes. An aqueous saturated sodium bicarbonate solution was slowly added dropwise to the reaction solution, which was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate and concentrated. The obtained residue was purified by Yamazen Parallel Prep (Brand name; column: 3 L, inject column: 2 L, n-hexane:ethyl acetate=40:60) to give the title compound (3.81 g) having the following physical data.

Provenance & Evidence