Hydrochloric Acid → HCID 11374125, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound 44 (3.7 g) in methanol (37 mL) was added dropwise 2N aqueous sodium hydroxide solution (11 mL) at 0° C. The solution temperature was risen to room temperature and the solution was stirred for 45 minutes. After the reaction solution was cooled to 0° C., 2N hydrochloric acid was added thereto and the solution was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and concentrated. The obtained residue was purified by flush column chromatography (n-hexane:ethyl acetate=1:1) to give the title compound (2.95 g) having the following physical data.

Provenance & Evidence