Hydrogen Peroxide → HCID 66859765, compound

Participants

Reaction Steps

To a solution of methyl 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo -1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylate (methyl ester of compound 8-1) (78.0 mg) in methanol (1.0 mL) were added sodium tungstate(VI) dihydrate (14.0 mg) and 30% hydrogen peroxide solution (0.19 mL) at 0° C. and the solution was stirred for 1 Hour and then for 3 Hours at room temperature. Water was added to the reaction solution, which was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated. The obtained residue was purified by column chromatography on silica gel (n-hexane:ethyl acetate=2:3) to give the title compound (70.4 mg) having the following physical data.

Provenance & Evidence